ABSTRACT
Introduction: SARS-CoV-2 infection is frequently associated with coagulation disorders and an increased risk of thromboembolic complications that may involve multiple vascular territories, with potentially fatal consequences. Case Series: We present six patients with confirmed COVID-19 who developed confirmed or suspected venous, arterial, or cardiac thromboembolic complications. Patients ranged in age from 54 to 79 years (mean, 64.4 years). All exhibited progressive increases in ferritin levels during hospitalization, while elevated inflammatory markers and dynamic D-dimer changes were observed in association with thromboembolic events. Despite prophylactic or therapeutic anticoagulation, severe complications still occurred. Three patients died from suspected intra-atrial mass, acute femoral and popliteal artery occlusion, and fulminant massive pulmonary thromboembolism, respectively. Conclusions: This case series highlights the systemic and heterogeneous nature of COVID-19-associated thromboembolism, which may occur despite anticoagulant prophylaxis, affect multiple vascular territories, and develop even in the absence of traditional thrombotic risk factors.