Introduction: Wellens’ Syndrome is indicated by deeply inverted or biphasic T-waves in V2-V3 precordial leads without ST elevation or pathological Q waves, immediately following an episode of angina pectoris. Case presentation: A case of Wellens’ syndrome depicted by coronary CT angiography (CTA) and invasive coronary angiography is reported. Conclusion: Recognition of these ECG changes is important, due to the imminent danger of acute LAD occlusion. Patients with Wellens’ syndrome should undergo invasive coronary angiography without delay. Ischemia provocation tests (i.e. treadmill) are contraindicated in these patients.